As reported by Deadline, apparently Amazon Studios are closing in on a deal to adapt the series in some way for Amazon Prime.
The series saw its return this year with the release of Mass Effect Legendary Edition that remastered the original trilogy, and we know now the series will continue with a Mass Effect 4 at some point in the future.
If you recall, actor Henry Cavill, no strangers to video game adaptations, seemed to be teasing something Mass Effect related, so it may be connected.