An interview with JoJo’s Bizarre Adventure character designer Masanori Shino revealed that Anasui could have been a woman in the anime version of Stone Ocean.
JoJo’s Bizarre Adventure: Stone Ocean will air episodes 13 to 24 on Netflix in Fall 2022.
This may be why he told the anime staff that if they wished to portray Anasui as a woman for the entire show, then they may.
Hirohiko Araki, the original creator of JoJo’s Bizarre Adventure, had apparently given the staff permission.