Todd Howard has assured Fallout fans that the franchise’s recently-released TV show does not contradict the games’ pre-established lore.
However, Bethesda’s Todd Howard has stated the show’s timeline of events is accurate, and doesn’t interfere with the already-established Fallout canon.
In an interview with IGN, Howard confirmed Shady Sands was nuked after the events of Fallout: New Vegas.
Essentially, the bombing of Shady Sands is as a catalyst for many of the show’s events.